Development of a Highly-Sensitive Targeted Cell-Free DNA Epigenomic Assay for Early-Stage Multi-Cancer Screening
A blood-based cancer screening test should exhibit performance metrics optimized for the cancer of interest…
Review the ECLIPSE study published in New England Journal of Medicine. See the data
04/11/2022
A blood-based cancer screening test should exhibit performance metrics optimized for the cancer of interest…
in real-world clinical settings for colorectal cancer (CRC) screening1*
Proven accuracy in the pivotal ECLIPSE† trial, with 83% sensitivity and 90% specificity2‡§
*Compliance rate for the first 8,000 patients that were prescribed Shield and completed it.1
†The ECLIPSE study (NCT04136002) is comparing the sensitivity and specificity of cfDNA only Shield with findings from subsequent colonoscopy in over 10,000 average-risk patients.1,2
‡Specificity detected for advanced neoplasia defined in ECLIPSE as CRC or advanced adenomas.1,3
§Patients had no prior diagnosis of CRC, inflammatory bowel disease, or family history of genetic risk for CRC (eg, Lynch syndrome).3
References: 1. Data on file. Guardant Health, Inc. 2. Guardant Health press release. December 15, 2022. 3. ECLIPSE trial on ClinicalTrials.gov
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